The Arroyo lab research focuses on the molecular mechanisms involved in the functioning of trophoblast cells and apoptosis, as well as the regulation of cell invasion during complicated pregnancies such as intrauterine growth restriction (IUGR), preeclampsia (PE) and preterm delivery (PT). We are also interested in the role of mTOR family proteins in placental and trophoblast development and functioning across gestation during these diseases.
Preterm delivery, preeclampsia and intrauterine growth restriction are complications that affect 10% of all pregnancies. Some of the characteristics of these diseases are abnormal placentation, abnormal growth of the fetus, increase in systemic blood pressure, increase in trophoblast apoptosis and others. Trophoblasts are specialized epithelial cells responsible for facilitating the exchange of nutrients and wastes between maternal and fetal compartments. As such, deviation from normal trophoblast functioning may play a significant factor in the development of these complications during pregnancies.