Welcome to the Arroyo Lab

 
Regulation of cell invasion during complicated pregnancies

Our Focus

 The Arroyo lab research focuses on the molecular mechanisms involved in the functioning of trophoblast cells and apoptosis, as well as the regulation of cell invasion during complicated pregnancies such as intrauterine growth restriction (IUGR), preeclampsia (PE) and preterm delivery (PT). We are also interested in the role of mTOR family proteins in placental and trophoblast development and functioning across gestation during these diseases. 

Preterm delivery, preeclampsia and intrauterine growth restriction are complications that affect 10% of all pregnancies. Some of the characteristics of these diseases are abnormal placentation, abnormal growth of the fetus, increase in systemic blood pressure, increase in trophoblast apoptosis and others. Trophoblasts are specialized epithelial cells responsible for facilitating the exchange of nutrients and wastes between maternal and fetal compartments. As such, deviation from normal trophoblast functioning may play a significant factor in the development of these complications during pregnancies.

Dr. Arroyo

Juan Arroyo, PhD

3052  LSB
Provo, UT 84602
jarroyo@byu.edu

Lab Number: (801) 422 -3798
Office Number: (801) 422-3221
Assistant Professor of Physiology
& Developmental Biology


Curriculum Vitae


Trophoblast Invasion
The Arroyo lab is attempting to determine mTOR, hyperosmolarity and apoptosis mechanisms that could be affecting placental trophoblast functioning and invasion during hemochorial placentation. Through this research our lab seeks to provide insights into the physiological relevance of these pathways in the pathogenesis of IUGR, PE and PT.

 


                                 
 pmTOR in Trophoblast Cells