Ya-Fang (Kary) Tsai
Dr. Juan Arroyo
A pattern of damaged DNA accumulation in disease placentas has been linked to poor pregnancy outcomes and undesired conditions for the fetus. The nuclear isoform of the receptor of advanced glycation end-products (RAGE) has recently been described on its vital role in DNA damage response. We sought to determine the role of nuclear RAGE in human placental DNA repair.